Cohost Jamie Lynn Sigler’s husband filled in on the April 21 episode of the actresses’ “MeSsy.”

Christina Applegate misses first podcast episode since reported hospitalization

Cohost Jamie Lynn Sigler's husband filled in on the April 21 episode of the actresses' "MeSsy."

By Marina Watts

Marina Watts

Marina Watts is a news writer for with seven years experience covering entertainment, pop culture and celebrity news. Her previous work appears in PEOPLE, Bustle and Newsweek.

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April 21, 2026 1:10 p.m. ET

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Christina Applegate in Los Angeles in 2024. Credit:

Emma McIntyre/Getty

- Christina Applegate is absent from the latest episode of her and Jamie Lynn Sigler's podcast *MeSsy* after Applegate was reportedly hospitalized.

- The *Dead to Me *actress has been open on her podcast, social media accounts, and elsewhere about her health journey living with multiple sclerosis.

- Applegate spoke out on Monday after reports of her hospitalization, thanking fans for their "outpouring of love and well wishes."

Christina Applegate has yet to return to the recording studio following reports of hospitalization.

The actress was absent from the Tuesday, April 21, episode of the *MeSsy *podcast, which she cohosts with Jamie Lynn Sigler and wherein they discuss their health journeys with multiple sclerosis. At the start of the episode, Sigler mentioned that the *Anchorman** *star was absent. Sigler's husband, Cutter Dykstra, stepped in.

"Hello, everybody. Welcome to *MeSsy*. This is just Jamie today, but not just Jamie," the *Sopranos** *actress began. "You know, life is happening. People are busy, and I'm very excited to have a conversation with somebody that probably knows me better than anyone in this world." The episode focused on caregivers and their relationships as Sigler navigates the chronic illness.

Applegate; Jamie Lynn Sigler.

Matt Winkelmeyer/Getty; Michael Loccisano/Getty

Applegate announced her multiple sclerosis diagnosis on social media in 2021 and has been candid about her health journey since, between her podcast and her recently published memoir *You With the Sad Eyes*. On April 16, TMZ reported that Applegate was hospitalized and had been receiving medical treatment since March.

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“I have no comment on whether she is in the hospital or what her medical treatments are,” Applegate’s rep told ** responding to TMZ's report. “She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.”

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Days later, Applegate returned to Instagram but made no mention of being in the hospital. "Thank you for the outpouring of love and well wishes," she wrote in an Instagram post on Monday.

"Health issues are a constant for me, but I’m a strong chick and I’m getting stronger and better every day. I’m taking a moment to focus on my health, but I’ll be back with more to say soon enough."

Applegate in Los Angeles in 2020.

Steve Granitz/WireImage

In a November 2024 episode of *MeSsy*, Applegate detailed the symptoms of MS that she experiences and how it can be different for anyone who shares the diagnosis. “I lay in bed screaming,” Applegate said at the time. “Jamie and I have different — everybody has different ways of it showing up. I lay in bed screaming. Like, the sharp pains, the ache, that squeezing.”

“Jamie knows that I just lay in bed all the time. I mean, I worked for almost 50 years, so I'm kind of okay with it,” Applegate said at another point in the episode.

“But if I put my feet on the ground and they're hurting like extraordinarily bad to the touch, I was like, ‘Yep. Gonna get back in my bed and pee in my diaper because I don't feel like walking all the way to the damn bathroom.’ "

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